1. What is the HOMA-IR Index?

The HOMA-IR (Homeostatic Model Assessment of Insulin Resistance) index is a method used to quantify insulin resistance. It provides an estimate of insulin sensitivity based on fasting plasma insulin and glucose levels.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR formula:

Where:

• \( FPI \) — Fasting Plasma Insulin (μU/mL)
• \( FPG \) — Fasting Plasma Glucose (mmol/L)
• 22.5 — Normalization constant

Explanation: The equation calculates insulin resistance by assessing the relationship between fasting insulin and glucose levels, with higher values indicating greater insulin resistance.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is widely used in clinical research and practice to identify insulin resistance, which is associated with type 2 diabetes, metabolic syndrome, and cardiovascular diseases.

4. Using the Calculator

Tips: Enter fasting plasma insulin in μU/mL and fasting plasma glucose in mmol/L. Both values must be valid and greater than zero for accurate calculation.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal HOMA-IR value?
A: Typically, values below 2.0 are considered normal, though this may vary by population and laboratory standards.

Q2: When should HOMA-IR be measured?
A: Measurement should be done after an overnight fast (8-12 hours) for accurate results.

Q3: Are there limitations to the HOMA-IR index?
A: Yes, it's less accurate in individuals with impaired beta-cell function and may not reflect dynamic changes in insulin sensitivity.

Q4: Can HOMA-IR be used for diagnosis?
A: While useful for assessing insulin resistance, it should be used alongside other clinical assessments rather than as a standalone diagnostic tool.

Q5: How often should HOMA-IR be monitored?
A: Frequency depends on individual risk factors and clinical context, typically monitored during metabolic health assessments.